Welcome to predictdnahth!

For a prediction of whether a given three-dimensional protein structure contains a DNA-binding helix-turn-helix (HTH) structural motif, please input the PDB ID of a structure to be tested. Results will be sent via e-mail if an address is provided.

     PDBID: 
     EMAIL ADDRESS:

Or upload a structural file in pdb format to determine whether the structure contains a DNA-binding HTH motif. Please use this mode for recent structures.

     COORDINATE FILE: 
     EMAIL ADDRESS:

** Check out the predictions made on July 25, 2003 during a search of the entire Protein Data Bank for the DNA-binding HTH motif. July 25, 2003 predictions

A comparison of two examples of the DNA-binding HTH motif. On the left is LexA repressor PDBID = 1LEA (a known member of the motif) and the right is a fragment of Esa1 Histone Acetyltransferase PDBID = 1FY7 (a new example). Graphics by PyMOL.

If you have any questions or comments, please contact Bill McLaughlin.

Reference:
McLaughlin WA, Berman HM. Statistical models for discerning protein structures containing the DNA-binding helix-turn-helix motif. J Mol Biol. 2003 Jun 27;330(1):43-55.